Specific molecules called cytokines regulate the immune response. They are responsible for cell communication that signals cells going to the area of inflammation. They are also referred to as immunomodulating factors. Cytokines play a major role in the immune response, both innate and adaptive.

Activation of immunomodulating agents as a response to a foreign matter that might harm the body is called inflammation. It is the typical response of the body to trauma and infection. There are also abnormal immune responses; these abnormal conditions fall under autoimmune diseases.
An autoimmune response is the result of increased levels of cytokines in the human body. In the case of autoimmune response, the immune system that should protect the body recognizes the normal cell as a threat and destroys them instead. As this happens, the pattern of cell growth and development is altered. This alteration in the normal body process leads to abnormal growth or, in the worst case scenario, function loss.

Autoimmune Diseases Can Cause Hair Loss

Inflammation can cause a number hair loss conditions. For instance, Cicatricial alopecia is a type of autoimmune disease that attacks the sebaceous gland and stem cells in the upper part of the hair follicles. As a result, scar tissues replace the affected area. This is the reason why Cicatricial alopecia is also known as scarring alopecia.

Alopecia areata is a condition wherein inflammation damages the roots of the follicles. It stops the flow and supply of nutrients which weakens the follicles and contributes to hair loss. Round patches characterize this type of hair loss.

Another example of an autoimmune disease is Seborrheic eczema or Seborrheic dermatitis. Fungus and excessive oil is the primary cause of irritation to the human skin and scalp. Seborrheic eczema results to redness, scaly patches, and dandruff on the scalp. Infants might have this condition due to hormonal changes that stimulate oil glands to produce more oil. It is also known as crib cap.

JAK Inhibitors

The Columbia University continues to study and experiment with the great potential for JAK inhibitors. These inhibitors were developed to interfere the signal pathways of the JAK family, or Janus kinase. The JAK family contains four tyrosine kinase affiliates (JAK 1, JAK 2, JAK 3, and TYK 2) that aid in the simulation of cytokines which cause inflammation.

In cases of autoimmune disease, JAK inhibitors are necessary to stop the overproduction of cytokines and prevent further inflammation. These products were initially used to treat Alopecia areata. Since then, Columbia University continued to study and research the potential effects of JAK inhibitors for treating skin and hair loss problems.

Recently, the Science Advances Journal published another breakthrough in the study of JAK inhibitors made by Columbia University. It focuses on two JAK inhibitors, ruxolitinib and tofacitinib, both of which serve as a potential treatment for Alopecia areata and other scalp and hair problems. The function of these drugs is to stop the activity of the JAK family in the human body. Abnormal activity of the JAK enzyme results in a wide range of diseases that includes hair loss.

During the study, the researchers injected two completely hairless rats with ruxolitinib and tofacitinib. Hair regrowth and development among the mice became noticeable after five days. This is considered a significant time discovery in the treatment of hair loss and hair problems for both men and women.
Columbia University encourages further comprehensive studies on the effect of ruxolitinib and tofacitinib in the prevention and treatment of hair loss. This is also to ensure safety among consumers.
Food and Drug Administration (FDA) approved the use of tofacitinib for the treatment of rheumatoid arthritis. The Yale University accidentally found it, but due to questions of safety, they blocked the use of tofacitinib in treating other diseases.

On the other hand, Columbia University developed Jakabi Ruxolitinib tablets. The tablets were utilized for the treatment of alopecia areata in 2014. It was carefully studied and investigated. After taking the capsules for four months, the three men experiencing hair loss had full hair regrowth.
This milestone discovery by Columbia University significantly impacted the medical research on JAK inhibitors. They have recognized that it is more efficient to use ruxolitinib and tofacitinib as a topical medication rather than to take it orally.

As a result, thorough and comprehensive studies will be developed to assess the effectiveness of the two JAK inhibitors further. These experiments will focus on the safety precautions and long-term effectivity of JAK inhibitors.

Hair Loss in Women

Hair is a major factor for beautification among ladies. Women consider their hair as their crowning glory that shows off their style and personality. Thus, hair loss can be a damaging factor both in psychological and emotional aspects.

Female pattern hair loss (FPHL) is the common cause of hair problems among women. It is also referred to as androgenetic alopecia. It is a distinct type of hair loss that causes thinning, shedding and decreasing volume of hair on the scalp. Genetic and hereditary factors are considered to be the two main reasons of FPHL. This usually occurs after the menopausal age which is between ages 45-55.

Follione Hair Growth Serum contains a natural JAK inhibitor that is recommended specifically for women who are experiencing hair loss. It helps in the treatment and prevention of hair thinning and hair loss problem among women. Follione Hair Growth Serum for WOMEN enhances women’s appearance by:

  • Restoring healthy hair with the stimulation of hair growth
  • Extending the hair life cycle by strengthening and increasing its vitality
  • Eliminating alcohol-based substance that irritates scalp due to dryness
  • Preventing hair loss

Follione Hair Growth Serum for WOMEN contains ingredients that are tested and safe to use. The main active ingredient, Diaminopyrimidine Oxide, prohibits the consolidation of collagen, prevents hair loss, and extends the life cycle of hair, while promoting hair growth, enhanced strength, and vitality. Other components include natural JAK inhibitors, copper peptides, plant extracts, and phytochemicals

Scalp Therapy for Men and Women

Follione DHT Scalp Therapy has the big three formulae that help in scalp rejuvenation. The big three includes antiandrogens, growth stimulants, and anti-inflammatories. The product was created for men and women who have patches of hair loss caused by androgenetic alopecia. The product also contains natural JAK inhibitors approved by the Food and Drug Administration (FDA).


It is known that Panadoxine P and Ajuga cell components in Follione DHT Scalp Therapyinterfere in the conversion of testosterone to DHT hormone, one of the main reasons for hair loss. Other ingredients include Wedelolactone, polysaccharides, baicalin, formononetin, troxerutin and plant extracts that commonly helps in the prevention of hair loss and inflammation.
Illness, aging, hormonal changes and familial history are the common factors affecting hair loss both in men and women. Use Follione DHT Scalp Therapy at the early stage of balding and hair thinning. You do not have to worry about using these products because Follione offers scientific evidence as a proof of the effectiveness of the treatment regime.

Tropical Plant With Jak Inhibitor

Litsea Glutinosa or lawat is a type of tropical plant that is locally used as a food, medicine, and commoditu. It is mainly found in Asian countries including southern China, India, Myanmar, Thailand, Cambodia, Laos, Vietnam, Malaysia, Indonesia, and the Philippines.

Litsea Glutinosa stops hair thinning and hair loss, treats inflammation, relieves itchiness and aids in the growth and development of hair. It also contains natural JAK inhibitors known as Brevilin A. The scalp can quickly absorb natural JAK inhibitors more readily than artificial shampoos and conditioners.
Brevilin A has essential fatty acids which serve as food or nutrients needed in the rejuvenating process of the scalp that will help in the growth and strengthening of the hair. The National Center for Biotechnology Information (NCBI) and the US National Library of Medicine published a study that Litsea Glutinosa interferes in the signal from STAT 3, which is an oncoprotein that is instrumental in the growth and multiplication of tumors, cancer cells and even in autoimmune diseases.

Medical studies on the treatment of hair loss and scalp problems are still ongoing. Research made with JAK inhibitors are the basis of future breakthroughs that will aid in the treatment of hair loss.

Setting Expectations

Hair is subjected to a lot damage due to the many products and treatments we use to clean and maintain it. Using too many strong hair products removes the natural oil from the hair and strips away its protective layers, which eventually results in hair thinning and hair loss.

There is still hope for those who suffer from hair loss. Follione discovered a better way of addressing hair loss, regardless of the cause. All of the ingredients are listed for you to use as a guide in determining the product and treatment to use that will be suitable for your condition.

Hair treatment is considered a slow process that may last up to several months. It often takes two years to reach the maximum results, and you must set your expectations according. The process needs patience, persistence, and consistency until you attain the results you desire.